X-INACTIVATION NORMALIZES O-GLCNAC TRANSFERASE LEVELS AND GENERATES AN O-GLCNAC-DEPLETED BARR BODY

O-GlcNAc Transferase (OGT) catalyzes protein O-GlcNAcylation, an abundant and dynamic nuclear and cytosolic modification linked to epigenetic regulation of gene expression.The steady-state levels of O-GlcNAc are influenced by extracellular glucose concentrations suggesting that O-GlcNAcylation may serve as a metabolic sensor.Intriguingly, human OGT

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